One-pot synthesis of hexahydro-4H-chromens via rhodium-catalysed tandem hydroformylation starting from 1,5-dienes

doi:10.1016/S0040-4039(99)01594-4

Tetrahedron Letters

Volume 40, Issue 42, 15 October 1999, Pages 7455-7456

https://doi.org/10.1016/S0040-4039(99)01594-4 Get rights and content

Abstract

A convenient one-pot preparation of substituted hexahydro-4H-chromens via rhodium catalysed tandem hydroformylation starting from 1,5-dienes is described. The multi-step procedure starts with a hydroformylation of one double bond followed by carbonyl ene reaction, a second hydroformylation and enol ether forming cyclisation.

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One-pot synthesis of hexahydro-4H-chromens via rhodium-catalysed tandem hydroformylation starting from 1,5-dienes

Abstract

Flavour and Fragrance J.

Eur. J. Org. Chem.

Chem. Lett.

Angew. Chem.

Chem. Rev.

Angew. Chem.

Angew. Chem. Int. Ed.

J. Mol. Catal.

Catalysis of Organic Reactions

New J. Chem.