Magnesium ion mediated stereospecific formation of N-substituted ethanolamines during reductive amination

doi:10.1016/S0957-4166(00)82370-8

Tetrahedron: Asymmetry

Volume 1, Issue 3, 1990, Pages 163-166

https://doi.org/10.1016/S0957-4166(00)82370-8 Get rights and content

Abstract

Reductive amination of (R)-O-protected-α-hydroxyketone 1 with primary amines by NaBH₄ in the presence of Mg(ClO₄)₂ led to the exclusive formation of erythro (1R,2S)-O-protected-N-substituted ethanolamines 2, (R - methyl, ethy;, i-propyl, benzyl, phenylethyl).

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Magnesium ion mediated stereospecific formation of N-substituted ethanolamines during reductive amination

Abstract

Tetrahedron Lett.

Tetrahedron

Synthesis

J. Am. Chem. Soc.

J. Chem. Soc. Perkin Trans. I