Clinical InvestigationSurgeryAutologous bone marrow mononuclear cell transplantation in patients undergoing coronary artery bypass grafting
Section snippets
Selection criteria
All patients undergoing CABG at our institution were prospectively screened for inclusion in the investigation. Consecutive patients with the following characteristics were selected for inclusion in the study:
- 1.
recent MI (>4 weeks but <6 months);
- 2.
planned CABG for at least 2 vessels,
- 3.
no evidence of myocardial viability in the infarct area, as shown by a preoperative low-dose dobutamine echocardiography.
Patients were excluded in the following instances:
- 1.
age >80 years;
- 2.
left ventricular ejection fraction
Results
Baseline clinical features of the study population are shown in Table I.
Patients with inferior or posterior MI did not undergo revascularization of the infarct-related vessel, whereas patients with anterior or apical MI did.
Discussion
It has been accepted for a long time that cardiac cell death results in an irreparable damage to the structure of the adult heart. However, recent research has challenged the dogmatic notion that the heart represents a terminally differentiated postmitotic organ incapable of self-renewal.21 As a matter of fact, both preclinical studies in animal models and preliminary clinical investigations have suggested that stem cell therapy may promote cardiac angiogenesis and cell regeneration, thereby
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