International Journal of Oral and Maxillofacial Surgery
Invited Review PaperOsteobiologyIs autologous platelet concentrate beneficial for post-extraction socket healing? A systematic review
Section snippets
Materials and methods
A literature search was carried out on electronic databases (MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials), using the following search terms, alone and in combination by means of Boolean operators: ‘platelet-rich plasma’, ‘autologous platelet concentrates’, ‘platelet growth factors’ and ‘platelet-rich fibrin’. The search was limited to studies involving human subjects. No language or time restriction was applied. The last electronic search was performed on October 2010.
A
Results
The electronic search provided 424 articles. One additional article71 was identified by hand searching. Figure 1 illustrates the selection process. After screening the titles and abstracts, 11 articles, reporting on 12 comparative studies assessing the effect of platelet concentrates on the treatment of extraction sockets were identified. After review of the full text, one article62 was excluded because platelet concentrate was used in both treatment groups, another article7 was excluded
Discussion
The response of living tissues to all forms of injury is inflammation, which involves humoral and cellular reactions at the site of injury and prepares the site for healing. The latter is a complex and prolonged process based on a cascade of biological events controlled by a number of biologically active growth and differentiation factors and cytokines.
A recent strategy to promote the wound-healing cascade is to prepare an autologous platelet concentrate suspended in a small plasma volume, and
Funding
None.
Conflict of interest
None declared.
Ethical approval
Not required.
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