Basic and patient-oriented researchEffects of Simvastatin on Mandibular Distraction Osteogenesis
Section snippets
Materials and Methods
A total of 18 New Zealand rabbits, weighing about 2 kg, were used as experimental animals. The animals were kept in cages and fed a solid diet and given water ad libitum. The protocol of the experiment was approved by the Animal Care and Use Committee at Cumhuriyet University, Sivas, Turkey.
The animals were divided into 3 study groups, and a unilateral mandibular distraction osteogenesis procedure was applied to all animals. In group 1 (local application) a simvastatin gelatin sponge was
Results
The experimental procedures were well tolerated by all animals. Rabbits were able to feed normally. Malocclusion occurred in all rabbits, and the lower incisors elongated markedly. Superficial pinhole infection was observed in some of the animals. Gross examination of the distracted mandible indicated bony union across the distraction zone at the time of death. No adverse effects were observed in any of the animals because of simvastatin treatment.
Plain radiographic evaluation showed
Discussion
Physiologic strain plays a key role in the growth and maintenance of the skeletal system, and distraction osteogenesis is a method of producing bone by mechanical distraction forces. The molecular mechanism that translates the mechanical forces into cellular events is not fully understood, but it has been determined that distraction osteogenesis stimulates the production of osteoinductive growth factors. The studies on molecular biology of distraction osteogenesis showed that BMPs are central
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