Biomimetic self-assembly of calcium phosphate templated by PNIPAAm nanogels for sustained smart drug delivery
Graphical abstract
PNIPAAm/CaP hybrid nanocomposites with dual-responsive sustained drug delivery property had been prepared by in-situ biomineralization process. The interaction among PNIPAAm, PAA and Ca2+ contributed the homogeneous morphology and the smart drug release property of the nanocomposites.
Highlights
► PNIPAAm/CaP hybrid nanocomposites were prepared by biomimetic self-assembly. ► The interaction between PAA and Ca2+ enabled the homogeneity and robustness of nanocomposite. ► Drug release behaviors were pH- and thermal-responsive. ► The release profile was sustained with the introduction of CaP.
Keywords
Biomimetic
Nanocomposites
pH/temperature responsive
Self-assembly
Smart drug delivery
Cited by (0)
Copyright © 2012 Elsevier B.V. All rights reserved.