The authors conducted a set of studies concerning the development of methodological support of multivariate predictive control reliability system for oil and gas industry. The algorithms, the innovative methods of calculation and the mathematical models of reliability factors, compatible with the modern production technological maintenance system, the system of dispatcher data registration, non-destructive testing diagnostics, and automated process control systems are developed. The mathematical software is designed to meet the technological features of the specific facilities, with applying the theory of process analysis, theory of reliability and fluctuation analysis elements. The developed models of reliability factors provide the possibility of predicting the parameters of technical facilities in a real time mode or for a fixed period, the structural and factor analysis function of the system in order to plan its optimal maintenance.