Elsevier

Tetrahedron Letters

Volume 46, Issue 20, 16 May 2005, Pages 3537-3540
Tetrahedron Letters

Gymnocin-B with the largest contiguous polyether rings from the red tide dinoflagellate, Karenia (formerly Gymnodinium) mikimotoi

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Abstract

A new cytotoxic polyether, gymnocin-B, was isolated from the red tide dinoflagellate, Karenia mikimotoi. Its structure was characterized by 15 contiguous ether rings and a 2-methyl-2-butenal side chain. Gymnocin-B showed cytotoxicity against P388 cells.

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Acknowledgements

We are grateful to Mr. T. Yano, Miss A. Konno, M. Shoji, and Miss M. Abe of Tohoku University for culturing K. mikimotoi and purification of gymnocins. This work was supported by grant-in-aid from the Ministry of Education, Science, Sports and Culture, Japan (No. 13760080) and CREST.

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