Chaetominedione, a new tyrosine kinase inhibitor isolated from the algicolous marine fungus Chaetomium sp.
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The novel benzonaphthyridinedione derivative, chaetominedione, has significant inhibitory activity toward p56lck tyrosine kinase (93.6% enzyme inhibition at 200 μg/mL).
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Acknowledgments
The author wishes to express his sincere thanks to Professor G. M. König, Institute of Pharmaceutical Biology, Bonn, Germany, for the fungal strain and for performing the spectral analysis. This project is part of the DAAD project bioactive metabolites from marine derived fungi, Project code 134.104401.212.
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