Oral and maxillofacial surgeryThe effect of fluoxetine on bone regeneration in rat calvarial bone defects
Section snippets
Animals
Twenty-one male Sprague-Dawley rats (Razi Institute, Tehran, Iran) weighting 150-200 g at commencement of experiments were used in this study. The animals were housed in groups of seven in polycarbonate cage in a temperature-controlled (22 ± 3°C) colony room. They were maintained in a 12 hours on/12 hours off light/dark schedule with ad libitum food and water. Subjects were experimentally native, and each rat was used only once. Treatment groups consisted of 7 animals, and rats housed in the
Histologic observation
In this study, a total 21 experimental animals with 42 defects were analyzed for both histologic and histometric evaluation of calvarial defect. At 8 weeks, there was no adverse reaction around the remaining NBBM within the defects. Bone growth mainly was in the periphery of the defects and crept toward the center. In all specimens, no cartilage matrix was seen and the lamellar bone matrix was well formed. Bone-forming cells could be seen at the periphery, and their dense arrangement adjacent
Discussion
The regeneration of bone has long been the critical issue in osseous defects and around dental implants. Many procedures have been developed for the purpose of promoting regeneration, including guided tissue regeneration and bone grafts; therefore, factors with possible impact on bone regeneration would be of interest. In the present experiment, the data revealed that daily dosage of 15 mg fluoxetine synergistically with NBBM increased the amount of bone regeneration in rat calvarial defects.
References (30)
- et al.
Neurotransmitter action in osteoblasts: expression of a functional system for serotonin receptor activation and reuptake
Bone
(2001) - et al.
Expression of serotonin receptors in bone
J Biol Chem
(2001) Neurotransmitters as growth regulatory signals: role of receptors and second messengers
Trends Neurosci
(1993)- et al.
A new member of tumor necrosis factor ligand family, ODF/OPGL/TRANCE/RANKL, regulates osteoclast differentiation and function
Biochem Biophys Res Commun
(1999) - et al.
Platelet-rich plasmaGrowth factor enhancement for bone grafts
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
(1998) - et al.
R-Fluoxetine increases extra cellular DA, NE, as well as 5-HT in rat prefrontal cortex and hypothalamus: an in vivo microdialysis and receptor binding study
Neuropsychopharmacology
(2002) - et al.
Antidepressant-like effects in various mice strains in the tail suspension test
Behav Brain Res
(2003) - et al.
Use of selective serotonin-reuptake inhibitors of tricyclic antidepressants and risk of hip fracture in elderly people
Lancet
(1998) - et al.
Serotonin regulates osteoclast differentiation thorugh its transporter
J Bone Miner Res
(2004) - et al.
Inhibition of the serotonin (5-hydroxytryptamine) transporter reduces bone Accrual during growth
Endocrinology
(2005)
Serotonin and fluoxetine modulate bone cell function in vitro
J Cell Biochem
Long-term serotonin administration leads to higher bone mineral density, affects bone architecture, and leads to higher femoral bone stiffness in rats
J Cell Biochem
Serotonin as a regulator of craniofacial morphogenesis: site specific malformations following exposure to serotonin reuptake inhibitors
Teratology
BSP and RANKL induce osteoclastogenesis and bone resorption synergistically
J Bone Miner Res
Fluoxetine treatment increases trabecular bone formation in mice
J Cell Biochem
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Effects of social stress and fluoxetine treatment on fracture healing in a rat femur fracture model
2022, InjuryCitation Excerpt :However, a dual effect of fluoxetine was reported to increase bone mass impairing osteoclast differentiation in short-term treatment and increase bone resorption with a net effect of decreased bone formation in chronic treatment [25]. On the other hand, Mortazavi et al. [26] reported that fluoxetine increased bone formation in rats with calvarial small-size bone defects. However, serotonin and also fluoxetine were proposed to have an inhibitory effect on osteoprogenitor cells [27].
Serotonin and orthodontic tooth movement
2019, BiochimieCitation Excerpt :For instance, the use of certain SSRIs has been associated with decreased bone mineral density, both in children [65] and adults, the latter subject to higher rates of osteoporosis and greater risk of bone fracture [48,66,67,68,69,70]. However, several studies challenge these findings, reporting either no effects [71,72,73] or greater bone regeneration in calvarial defects when SSRIs are administered [59]. Discordant findings on the effects of SSRIs have also been published in relation to OTM.
INFLUENCE OF SEROTONIN ON THE METABOLISM OF BONE TISSUE
2022, Fiziologichnyi Zhurnal
Supported in part by a grant-in-aid from the Tehran University of Medical Sciences (Vice-chancellor for Research).