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The use of zeolites as slow release anthelmintic carriers

Published online by Cambridge University Press:  12 April 2024

A. Dyer ,
S. Morgan ,
P. Wells  and
C. Williams
A. Dyer
Affiliation:
Department of Chemistry, University of Salford, Salford, Lancashire, M5 4WT, UK
S. Morgan
Affiliation:
Department of Chemistry, University of Salford, Salford, Lancashire, M5 4WT, UK
P. Wells
Affiliation:
Department of Chemistry, University of Salford, Salford, Lancashire, M5 4WT, UK
C. Williams*
Affiliation:
Department of Chemistry, University of Salford, Salford, Lancashire, M5 4WT, UK
*
*Address for correspondence: School of Applied Sciences, University of Wolverhampton, Wolverhampton, WV1 1SB, UK, Fax: 01902 322680 E-mail: c.williams@wlv.ac.uk
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Abstract

This work examines the ability of commerical zeolite Y to act as a slow release agent for a number of anthelmintic drugs. Administration to rats, dosed with Nippostrongylus brasiliensis, of pyrantel and/or fenbendazole and pigs, dosed with Ascaris and Oesophagostomum, of dichlorvos (DDVP) loaded onto zeolite Y was more sucessful in killing adult worms than administration of the pure drug alone. The zeolite Y was used as supplied for initial studies and then later dealuminated for further studies. The drug loadings were monitored by thermal analysis and the loaded zeolites were used in several field trials. The results indicate that zeolite Y is a suitable vehicle for the slow release of some anthelmintics. The slow release of drug from the zeolite matrix improved its efficacy.

Type
Research Article
Information
Journal of Helminthology , Volume 74 , Issue 2 , June 2000 , pp. 137 - 141
Copyright
Copyright © Cambridge University Press 2000

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