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Optical resolution of 2-(3-indolyl)propionic acid with Mucor javanicus and α-chymotrypsin

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Abstract

Resolution of 2-(3-indolyl)propionic acid was achieved via biocatalytic hydrolysis of its chloroethyl ester. Of the enzymes tested, Mucor javanicus lipase (R selectivity) and α-chymotrypsin (S selectivity) had high reactivity and enantioselectivity (E value > 50). Neither enzyme showed enantioselectivity (E value = 1) for 2-phenylpropionic acid.

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Authors and Affiliations

  1. Department of Chemistry, National Industrial Research Institute of Nagoya, Hirate-cho, Kita-ku

    Katsuya Kato, Yue-fa Gong, Satoko Tanaka, Masato Katayama & Hiroshi Kimoto

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  1. Katsuya Kato
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  2. Yue-fa Gong
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  3. Satoko Tanaka
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  4. Masato Katayama
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  5. Hiroshi Kimoto
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Kato, K., Gong, Yf., Tanaka, S. et al. Optical resolution of 2-(3-indolyl)propionic acid with Mucor javanicus and α-chymotrypsin. Biotechnology Letters 21, 457–461 (1999). https://doi.org/10.1023/A:1005550806687

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  • DOI: https://doi.org/10.1023/A:1005550806687

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