Skip to main content
SpringerLink
Log in

Influence of the Structure of Steroid Hormones on Their Association with Cyclodextrins: A High-Performance Liquid Chromatography Study

  • Published:
Journal of inclusion phenomena and molecular recognition in chemistry Aims and scope Submit manuscript

Abstract

The association constants of fourteen steroid hormones with β- and γ-cyclodextrin were measured in methanol-water (20 : 80 v/v) at 35 °C using the chromatographic Hummel-Dreyer method. It was found that the greatest influence on the association constants is the structural features of ring A of these compounds but the substituents of ring D also alter the complex stability to an appreciable degree. The measured association constants were considerably greater than the corresponding values measured previously in the medium containing more methanol (45 instead of 20%).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. N. Sadlej-Sosnowska: Eur. J. Pharm. Sci. 3, 1 (1995).

    Google Scholar 

  2. B.L. Poh and Y.M. Chow: J. Incl. Phenom. 14, 85 (1992).

    Google Scholar 

  3. J. Taraszewska and A.K. Piasecki: J. Electroanal. Chem. 226, 137 (1987).

    Google Scholar 

  4. J. Taraszewska: J. Incl. Phenom. 10, 69 (1991).

    Google Scholar 

  5. D.W. Armstrong, F. Nome, L.A. Spino and T.D. Golden: J. Am. Chem. Soc. 108, 1418 (1986).

    Google Scholar 

  6. B. Agnus, B. Sébille and M. Gosselet: J. Chromatogr. 552, 583 (1991).

    Google Scholar 

  7. N. Sadlej-Sosnowska: J. Pharm. Biomed. Anal. 13, 701 (1995).

    Google Scholar 

  8. N. Yoza: J. Chem. Educ. 54, 284 (1977).

    Google Scholar 

  9. T.K. Korpela and J. P. Himanen: J. Chromatogr. 290, 351 (1984).

    Google Scholar 

  10. B. Sébille, N. Thuaud, J. Piquion and N. Behar: J. Chromatogr. 409, 61 (1987).

    Google Scholar 

  11. B. Sébille, R. Zini, C. V. Madjar, N. Thuaud and J. P. Tillement: J. Chromatogr. 531, 51 (1990).

    Google Scholar 

  12. L. Šoltés and B. Sébille: J. Liq. Chromatogr. 17, 2207 (1994).

    Google Scholar 

  13. K.A. Connors: Binding Constants–The Measurement of Molecular Complex Stability, Wiley, New York, 1987, pp. 50, 66.

    Google Scholar 

  14. Y. Matsui and K. Mochida: Bull. Chem. Soc. Jpn. 52, 2808 (1979).

    Google Scholar 

  15. J.C. Harrison and M.R. Eftink: Biopolymers 21, 1153 (1982).

    Google Scholar 

  16. M.L. Vazquez, C.M. Franco, A. Cepeda, P. Prognon and G. Mahuzier: Anal. Chim. Acta 269, 239 (1992).

    Google Scholar 

  17. W.V. Gerasimowicz and J.F. Wojcik: Bioorg. Chem. 11, 420 (1982).

    Google Scholar 

  18. A. Örstan and J.B.A. Ross: J. Phys. Chem. 91, 2739 (1987).

    Google Scholar 

  19. K. Králova and Ľ. Mitterhauszerová: Pharmazie 44, 623 (1989).

    Google Scholar 

  20. B. Siegel and R. Breslow: J. Am. Chem. Soc. 97, 6869 (1975).

    Google Scholar 

  21. G. Nelson, G. Patonay and I.M. Warner: Anal. Chem. 60, 274 (1988).

    Google Scholar 

  22. N.B. Elliot, T.T. Ndou and I.M. Warner: J. Incl. Phenom. 16, 99 (1993).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Drug Institute, Chelmska 30/34, 00-725, Warsaw, Poland

    Nina Sadlej-Sosnowska

Authors
  1. Nina Sadlej-Sosnowska
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sadlej-Sosnowska, N. Influence of the Structure of Steroid Hormones on Their Association with Cyclodextrins: A High-Performance Liquid Chromatography Study. Journal of Inclusion Phenomena 27, 31–40 (1997). https://doi.org/10.1023/A:1007964116987

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1007964116987

Search

Navigation