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Development of soluble glasses for biomedical use Part I: In vitro solubility measurement

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Abstract

In this study soluble glasses have been developed for biomedical applications containing P2O5 as a network former and CaO and Na2O as modifiers. This study shows that as expected, the glasses have an inverse exponential relationship between solubility and CaO content. Furthermore, there is evidence for compositional related non-linearity in the dissolution of the glasses with time. This is thought to be due to either layer formation on the glass surface hindering ion diffusion, ion exchange process or change of ionic strength of the solution. Bioactivity of these glasses is indicated by the formation of a brushite precipitate, a precursor to apatite formation. Further evidence for bioactivity is also presented in the second part of this paper.

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Authors and Affiliations

  1. Department of Biomaterials, Eastman Dental Institute, University College London, 256 Gray's Inn Road, London, WC1X 8LD, UK

    K. Franks & J. C. Knowles

  2. Queen Mary and Westfield College, Mile End Road, London, E1 4NS, UK

    I. Abrahams

Authors
  1. K. Franks
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  2. I. Abrahams
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  3. J. C. Knowles
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Franks, K., Abrahams, I. & Knowles, J.C. Development of soluble glasses for biomedical use Part I: In vitro solubility measurement. Journal of Materials Science: Materials in Medicine 11, 609–614 (2000). https://doi.org/10.1023/A:1008949527695

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  • DOI: https://doi.org/10.1023/A:1008949527695

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