Abstract
The aim of this study was to test C/C material (carbonized, graphitized or covered with pyrolytic carbon) designated for the use in orthopaedic and bone surgery. Using an in vitro assay we confirmed, that the cell proliferation was exhibited the mostly on the C/C composite coated with pyrolitic carbon and afterwards polished. The two latest of subsequent water extracts of this material had a slightly inhibiting effect on the cells metabolic activity. Biocompatibility test in vivo performed subcutaneously on rats did not show big differences between three tested implants (C/C composite, epoxy resine, titanium alloy), on the other hand the plates tested on pigs demonstrated foreign-body reaction induced by wear C/C composite material. Such debris were found both in the neighborhood of the implant as well as in the lymphatic node.
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References
E. FITZER, Carbon 25(1987) 163.
G. SAVAGE, “Carbon-carbon Composites” (Chapman and Hall, 1993).
G. M. JENKINS and F. X. DE CARVALHO, Carbon 15(1977) 33.
L. CLAES, E. FITZER, W. HUTTNER and K. KINZL, Carbon 18(1980) 383.
A. J. KLEIN, Adv. Mat. Process. Inc. Met. Prog. 130(1986) 64.
D. G. MENDES, M. ROFFMAN, M. SOUDRY, D. ANGEL, J. BOSS, Y. CHARIT, A. ROTEM, M. HUNT and D. MORDECHOVITCH, Orthopaedic Review 17(1988) 402.
V. PEšáKOVá, K. BALÎK and M. ADAM, Acta Chir. Orth. Traum. Čechosl. 59(1992) 302.
K. BALÎK, Z. WEISHAUPTOVá, P. GLOGAR, M. KLUĊáKOVá, V. PEšáKOVá and M. ADAM, Proceedings of the European Carbon Conference Carbon 96, Newcastle, UK, July 1996, 584.
J. VALENTA, “Biomechanics” (Academia, Prague 1993).
L. BAĊáKOVá, V. STARÝ and P. GLOGAR, Engineering of Biomaterials 3(1997) 3.
A. BRANDWOOD, K. R. NOBLE and K. SCHINDHELM, Biomaterials 13(1992) 646.
K. BALÎK, S. ŽIŽKA, Z. WEI SHAUPTOVá and M. ?ERNÝ, Ext. Abstracts of Eurocarbon 98, Strasbourg (1998) 655.
ISO 10993-5: Biological Evaluation of Medical Devices.
C. LAUGHTON, Anal. Biochem. 140(1984) 417.
Z. LOJDA, R. GOSSRAU and S. H. SCHIEBLER, “Enzymhistochemische Methoden”. Springer-Verlag, (Berlin: 1979).
N. J. HALLAB, K. J. BUNDY, K. O'CONNOR, R. CLARK and R. L. MOSES, Journal of Long-Term Effects of Medical Implants 5(1995) 209.
S. H. CARTMELL, P. J. DOHERTY, J. A. HUNT, D. M. HEALY and T. GILCHRIST, Journal of Materials Science: Materials in Medicine 9(1998) 773.
K. MURAI, F. TAKESHITA, Y. AYUKAWA, T. KIYOSHIMA, T. SUETSUGU and T. TANAKA, Journal of Biomedical Materials Research 30(1996) 523.
E. J. CHEAL, A. E. GRIERSON, D. T. REILLY, C. B. SLEDGE and M. SPECTOR, “Composite Materials for Implant Application in the Human Body. Characterization and Testing”, edited by R. D. Jamison and L. N. Gilbertson, (Philadelphia, USA 1993).
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PesÁkovÁ, V., Kle´zl, Z., Bali´k, K. et al. Biomechanical and biological properties of the implant material carbon-carbon composite covered with pyrolytic carbon. Journal of Materials Science: Materials in Medicine 11, 793–798 (2000). https://doi.org/10.1023/A:1008953529111
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DOI: https://doi.org/10.1023/A:1008953529111