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Fundamental Effects of Particle Morphology on Lung Delivery: Predictions of Stokes' Law and the Particular Relevance to Dry Powder Inhaler Formulation and Development

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Abstract

Key factors that contribute to the aerodynamic properties of aerosol particles are found in Stokes' law. These factors may be monitored or controlled to optimize drug delivery to the lungs. Predictions of the aerodynamic behavior of therapeutic aerosols can be derived in terms of the physical implications of particle slip, shape and density. The manner in which each of these properties have been used or studied by pharmaceutical scientists to improve lung delivery of drugs is readily understood in the context of aerosol physics. Additional improvement upon current aerosol delivery of particulates may be predicted by further theoretical scrutiny.

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Authors and Affiliations

  1. Department of Biomedical Engineering, University of North Carolina, Chapel Hill, North Carolina, 27599

    Timothy M. Crowder

  2. Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina, 27599

    Jacky A. Rosati

  3. Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina, 27599

    Jeffry D. Schroeter

  4. School of Pharmacy and Dept of Biomedical Engineering, University of North Carolina, Chapel Hill, North Carolina, 27599

    Anthony J. Hickey

  5. Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, University of North Carolina, Chapel Hill, North Carolina, 27599

    Ted B. Martonen

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  1. Timothy M. Crowder
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  2. Jacky A. Rosati
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  3. Jeffry D. Schroeter
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  4. Anthony J. Hickey
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  5. Ted B. Martonen
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Correspondence to Anthony J. Hickey.

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Crowder, T.M., Rosati, J.A., Schroeter, J.D. et al. Fundamental Effects of Particle Morphology on Lung Delivery: Predictions of Stokes' Law and the Particular Relevance to Dry Powder Inhaler Formulation and Development. Pharm Res 19, 239–245 (2002). https://doi.org/10.1023/A:1014426530935

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