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Pathogenesis and prevention of biomaterial centered infections

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Abstract

One of the major drawbacks in the use of biomedical materials is the occurrence of biomaterials centered infections. After implantation, the host interacts with a biomaterial by forming a conditioning film on its surface and an immune reaction towards the foreign material. When microorganisms can reach the biomaterials surface they can adhere to it. Adhesion of microorganisms to an implant is mediated by their physico-chemical surface properties and the properties of the biomaterials surface itself. Subsequent surface growth of the microorganisms will lead to a mature biofilm and infection, which is difficult to eradicate by antibiotics. The purpose of this review is to give an overview of the mechanisms involved in biomaterials centered infection and the possible methods to prevent these infections.

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Authors and Affiliations

  1. Department of Biomedical Engineering, University of Groningen, Faculty of Medical Sciences, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands

    B. Gottenbos, H. J. Busscher & H. C. van der Mei

  2. Department of Histology and Cell Biology, University of Groningen, Faculty of Medical Sciences, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands

    P. Nieuwenhuis

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  1. B. Gottenbos
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  2. H. J. Busscher
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  3. H. C. van der Mei
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  4. P. Nieuwenhuis
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Correspondence to H. J. Busscher.

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Gottenbos, B., Busscher, H.J., van der Mei, H.C. et al. Pathogenesis and prevention of biomaterial centered infections. Journal of Materials Science: Materials in Medicine 13, 717–722 (2002). https://doi.org/10.1023/A:1016175502756

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