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A study into the anti-microbial properties of an amino functionalised polymer using multi-parameter flow cytometry

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Abstract

Fluorescent staining techniques were used to study the anti-microbial properties of aqueous suspensions of a novel, water insoluble amino functionalised polymer on three micro-organisms Pseudomonas fluorescens, Staphylococcus epidermidis and Saccharomyses cerevisiae. The mechanism of action was similar for each organism in that, after various contact times with the polymer, a progressive change in individual cell physiological state was measured using multi-parameter flow cytometry. The microbiocidal activity of this polymer may be similar to that of substances referred to as polycationic, amphipathic compounds (peptides, peptide derivatives and other polyamines).

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Hewitt, C.J., Franke, R., Marx, A. et al. A study into the anti-microbial properties of an amino functionalised polymer using multi-parameter flow cytometry. Biotechnology Letters 26, 549–557 (2004). https://doi.org/10.1023/B:BILE.0000021954.82099.a0

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  • DOI: https://doi.org/10.1023/B:BILE.0000021954.82099.a0

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