The Hodgkin–Huxley theory that explains the mechanism of how neurons fire forms the cornerstone of computational neuroscience. But something it hasn't predicted is happening in the brain cortex.
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References
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Gutkin, B., Ermentrout, G. Spikes too kinky in the cortex?. Nature 440, 999–1000 (2006). https://doi.org/10.1038/440999a
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DOI: https://doi.org/10.1038/440999a
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