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Osmotic stress

Is CoQ a membrane stabilizer?

Coenzyme Q10 is an essential lipid in aerobic respiratory metabolism and a membrane antioxidant. A new function is revealed for CoQ; as a membrane-stabilizing agent that enhances resistance of bacterial cell and liposome membranes to salt stress.

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Figure 1: Osmotic stress response and membrane stability.

References

  1. Turunen, M., Olsson, J. & Dallner, G. Biochim. Biophys. Acta 1660, 171–199 (2004).

    Article  CAS  Google Scholar 

  2. Sevin, D.C. & Sauer, U. Nat. Chem. Biol. 10, 266–272 (2014)

    Article  CAS  Google Scholar 

  3. Wood, J.M. Annu. Rev. Microbiol. 65, 215–238 (2011).

    Article  CAS  Google Scholar 

  4. Haines, T.H. Prog. Lipid Res. 40, 299–324 (2001).

    Article  CAS  Google Scholar 

  5. Quinn, P.J. Prog. Lipid Res. 51, 179–198 (2012).

    Article  CAS  Google Scholar 

  6. Hauss, T., Dante, S., Haines, T.H. & Dencher, N.A. Biochim. Biophys. Acta 1710, 57–62 (2005).

    Article  CAS  Google Scholar 

  7. Genova, M.L. & Lenaz, G. Biochim. Biophys. Acta 1837, 427–443 (2014).

    Article  CAS  Google Scholar 

  8. He, C.H., Xie, L.X., Allan, C.M., Tran, U.C. & Clarke, C.F. Biochim. Biophys. Acta doi:10.1016/j.bbalip.2013.12.017 (7 January 2014).

  9. Emmanuele, V. et al. Arch. Neurol. 69, 978–983 (2012); erratum 69, 886 (2012).

    Article  Google Scholar 

  10. Gasser, D.L. et al. Am. J. Physiol. Renal Physiol. 305, F1228–F1238 (2013).

    Article  CAS  Google Scholar 

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Correspondence to Catherine F Clarke.

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Clarke, C., Rowat, A. & Gober, J. Is CoQ a membrane stabilizer?. Nat Chem Biol 10, 242–243 (2014). https://doi.org/10.1038/nchembio.1478

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