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Improved Estimation of Secondary Structure in Ribonucleic Acids

Nature New Biology volume 246, pages 40–41 (1973)Cite this article

Abstract

A SIMPLE method for estimating the most stable secondary structure of an RNA molecule from its sequence was proposed earlier1. This method can be used for predicting and assessing possible secondary structures for recently determined RNA sequences2–4. New experimental5–8 and theoretical9, 10 results allow us to improve the method, without making it more complicated.

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References

  1. Tinoco, I., jun., Uhlenbeck, O. C., and Levine, M. D., Nature, 230, 5293 (1971).

    Article  Google Scholar 

  2. Cory, S., Adams, J. M., and Spahr, P., J. molec. Biol., 63, 41 (1972).

    Article  CAS  Google Scholar 

  3. Adams, J. M., Spahr, P., and Cory, S., Biochemistry, 11, 976 (1972).

    Article  CAS  Google Scholar 

  4. Min Jou, W., Haegeman, G., Ysebaert, M., and Fiers, W., Nature, 237, 82 (1972).

    Article  CAS  Google Scholar 

  5. Fink, T. R., and Crothers, D. M., J. molec. Biol., 66, 1 (1972).

    Article  CAS  Google Scholar 

  6. Uhlenbeck, O. C., Borer, P. N., Dengler, B., and Tinoco, I., jun., J. molec. Biol., 73, 483 (1973).

    Article  CAS  Google Scholar 

  7. Gralla, J., and Crothers, D. M., J. molec. Biol., 73, 497 (1973).

    Article  CAS  Google Scholar 

  8. Gralla, J., and Crothers, D. M., J. molec. Biol., 78, 301 (1973).

    Article  CAS  Google Scholar 

  9. DeLisi, C., and Crothers, D. M., Proc. natn. Acad. Sci., U.S.A., 68, 2682 (1971).

    Article  CAS  Google Scholar 

  10. DeLisi, C., and Crothers, D. M., Biopolymers, 10, 1809 (1971).

    Article  CAS  Google Scholar 

  11. Martin, F. H., Uhlenbeck, O. C., and Doty, P., J. molec. Biol., 57, 201 (1971).

    Article  CAS  Google Scholar 

  12. Uhlenbeck, O. C., Martin, F. H., and Doty, P., J. molec. Biol., 57, 217 (1971).

    Article  CAS  Google Scholar 

  13. Jacobson, H., and Stockmayer, W. H., J. chem. Phys., 18, 1600 (1950).

    Article  CAS  Google Scholar 

  14. Wickstrom, E., thesis (University of California, Berkeley, 1972).

  15. Adams, J. M., Jeppeson, P. G. N., Sanger, F., and Barrell, B. G., Nature, 223, 1009 (1969).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Chemistry, University of California, Berkeley, California, 94720

    IGNACIO TINOCO JUN., PHILIP N. BORER, BARBARA DENGLER & MARK D. LEVINE

  2. Biochemistry Department, University of Illinois, Urbana, Illinois, 61801

    OLKE C. UHLENBECK

  3. Department of Chemistry, Yale University, New Haven, Connecticut, 06520

    DONALD M. CROTHERS & JAY GRALLA

Authors
  1. IGNACIO TINOCO JUN.
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  2. PHILIP N. BORER
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  3. BARBARA DENGLER
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  4. MARK D. LEVINE
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  5. OLKE C. UHLENBECK
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  6. DONALD M. CROTHERS
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  7. JAY GRALLA
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TINOCO, I., BORER, P., DENGLER, B. et al. Improved Estimation of Secondary Structure in Ribonucleic Acids. Nature New Biology 246, 40–41 (1973). https://doi.org/10.1038/newbio246040a0

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