Abstract
Self-assembly offers a promising method to organize functional nanoscale objects into two-dimensional (2D) and 3D superstructures for exploiting their collective effects1,2,3. On the other hand, many unique phenomena emerge after arranging a few nanoscale objects into clusters, the so-called artificial molecules4,5,6,7,8,9,10. The strategy of using biomolecular linkers between nanoparticles has proven especially useful for construction of such nanoclusters4,5,6,11,12,13,14,15,16. However, conventional solution-based reactions typically yield a broad population of multimers or isomers of clusters; furthermore, the efficiency of fabrication is often limited4,5,6,11,12,13,14,15,16. Here, we describe a novel high-throughput method for designing and fabricating clusters using DNA-encoded nanoparticles assembled on a solid support in a stepwise manner. This method efficiently imparts particles with anisotropy during their assembly and disassembly at a surface, generating remarkably high yields of well-defined dimer clusters and Janus (two-faced) nanoparticles. The method is scalable and modular, assuring large quantities of clusters of designated sizes and compositions.
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Acknowledgements
Research was supported by the US DOE Office of Science and Office of Basic Energy Sciences under contract No. DE-AC-02-98CH10866. M.M.M. acknowledges a Goldhaber Distinguished Fellowship at BNL sponsored by Brookhaven Science Associates.
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M.M.M., D.N., D. vdL. and O.G. contributed to the design of the experiment and manuscript preparation. M.M.M. and M.C. carried out the experiments. M.M.M., D.N. and O.G analysed data. O.G. directed the research.
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Maye, M., Nykypanchuk, D., Cuisinier, M. et al. Stepwise surface encoding for high-throughput assembly of nanoclusters. Nature Mater 8, 388–391 (2009). https://doi.org/10.1038/nmat2421
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DOI: https://doi.org/10.1038/nmat2421
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