Abstract
Morphometric and electrophoretic properties of soleus and medialis gastrocnemius fibres from paraplegic patients were studied 1 to 10 months following complete traumatic cord transection (spinal cord level C5-T1).
In the short term of paraplegia (1-6 months) gastrocnemius medialis and soleus muscles showed predominant atrophy of IIA fibre types. In long term paraplegia (8-10 months) atrophy and reduction of type 1 fibres, with presence of high percentages of type IIB fibres, were seen in both studied muscles. The consistence in both muscles of IIB intermediate fibres in long term paraplegia, seems to indicate the initial stage of a mechanism of fibre transformation reflecting the adaptative capacity of the paretic muscle to spasticity. Electrophysiological studies of the H-reflex and the HIM ratio values reveal an increase of the H-reflex excitability in the soleus and gastrocnemius muscles during a 1 to 10 months follow-up.
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Burke D 1983 Critical examination of the case for or against. Fusimotor involvement. In: Desmedt E (ed) Disorders of muscle tone in motor control mechanism in health and disease. Raven Press, New York. 133–150.
Carraro U, Dalla Libera, L, Catani C 1983 Myosin light and heavy chains in muscle regenerating in absence of the nerve:transient appearance of the embryonic light chain. Experimental Neurology 79: 106–117.
Dattola R, Girlanda P, Vita G et al 1988 Studio elettromiografico e morfologico delle alterazioni muscolari in pazienti emiparetici. Atti del congr. Soc. It. EEG Neurofisiol. Clin. Ancona 23-25 giugno 151.
Girlanda P, Dattola R, Vita G, et al 1987 Rimodellamento morfofunzionale del muscolo in soggetti con paraparesi spastica da lesione midollare. Atti del XXV Congr Soc It Neurol. Bologna 30 nov. -3dic. p. 217.
Goldkamp O 1967 Electromyography and nerve conduction studies in 116 patients with hemiplegia. Archives of Physical Medicine 48: 59–63.
Grimby G, Brobreg I, Krotkjewska I, Krotkjewski 1976 Muscle fibres composition in patients with traumatic cord lesion. Scandinavian Journal of Rehabilitation Medicine 8: 37–42.
Kondo A 1987 A mophometric study of myelinated fibers in the fifth lumbar ventral roots in patients with cerebrovascular diseases. Clinical Neuropathology 6: 250–256.
Khoubesserian P, Telerman Toppet, N, Welraeds D, Coers C 1983 Modifications des unités motrices chez des malades atteints de paraplégie traumatique. Revue Neurologique (Paris) 139: 635–647.
Kugelberg E, Edstrom L 1968 Differential histochemical effects of muscle contraction on Phosphorylase and glycogen in various types of fibres. Relation to fatigue. Journal of Neurology, Neurosurgery and Psychiatry 31: 415–423.
Lieber R, Johansson C A B, Vahlsing H L, Hargens A R, Feringa E R 1986 Long-term effects of spinal cord transection on fast and slow rat skeletal muscle I Contractile properties. Experimental Neurology 91: 423–434.
Lieber R, Friden J O, Hargens A R, Feringa E R 1986 Long-term effects of spinal cord transection on fast and slow rat skeletal muscle. II Morphometric properties. Experimental Neurology 91: 435–448.
Messina C, Girlanda P, Vita G, et al 1984 Rimodellamento funzionale e strutturale del muscolo nella patologia del motoneurone centrale. In: Compromissioni e ripresa della motilità: correlati neurofisiologici. Riv. It. EEG Neurofisiol. Clin. 53–58.
Scelsi R, Marchetti, C, Lotta, S, Lommi, G 1982 Muscle fiber type morphology in paraplegic patients with traumatic cord lesion. Acta Neuropathologica (Berlin) 57: 243–248.
Scelsi R, Lotta S, Lommi G, POGGI P, Marchetti C 1984 Hemiplegic Atrophy. Morphological findings in the anterior tibial muscle of patients with cerebral vascular accidents. Acta Neuropathologica (Berlin) 62: 324–331.
Tellerman Toppet N, Coers C 1971 A third muscle fibre type related to collateral reinnervation in motor neurone and peripheral nerve disease. Pathology Eur 6: 50–55.
Troni W, De Mattei, M, Cocito D, Torchio F 1988 Reperti elettrofosiologici nell'emiplegia. Atti congr. Soc. It. EEG Neurofisiol. Clin. Ancona 23-25 giugno 60.
West S P, Roland R R Reggie Edgerton V 1986 Fiber type and fiber size of cat ankle, knee and hip extensors and flexors following low thoracic spinal cord transection at an early age. Experimental Neurology 91: 174–182.
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Lotta, S., Scelsi, R., Alfonsi, E. et al. Morphometric and neurophysiological analysis of skeletal muscle in paraplegic patients with traumatic cord lesion. Spinal Cord 29, 247–252 (1991). https://doi.org/10.1038/sc.1991.35
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DOI: https://doi.org/10.1038/sc.1991.35
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