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Plasminogen-activator-inhibitor-1 promoter polymorphism as a risk factor for adult periodontitis in non-smokers

Genes & Immunity volume 3, pages 292–294 (2002)Cite this article

Abstract

Periodontal diseases belong to the most common chronic disorders affecting mankind. Smoking and impaired plasminogen activation with hypercoagulation and fibrinolysis inhibition have been proposed as having a role in predisposition to these diseases. We investigated relationships among adult periodontitis, smoking, and a variation in the deletion/insertion (4G/5G) promoter polymorphism of the plasminogen-activator-inhibitor-1 (PAI-1) gene in 304 Caucasian subjects. An association was detected between the deletion (4G) allele (and 4G/4G genotype) and periodontitis (P = 0.0022, Pcorr < 0.01; P = 0.014, Pcorr < 0.05). A stronger association occurred in non-smokers (P = 0.00021, Pcorr < 0.01; P = 0.0024, Pcorr < 0.05) where the presence of the PAI-1 gene 4G allele appears to be one of the risk factors for periodontitis.

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Acknowledgements

We would like to thank Andrea Stejskalova and Tomas Halabala for excellent technical assistance.

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Authors and Affiliations

  1. Department of Pathological Physiology, Medical Faculty, Masaryk University, Brno, Czech Republic

    L Izakovičová Hollá, D Bučková & P Beneš

  2. Department of Periodontology, Clinic of Stomatology, Medical Faculty, Masaryk University and St’Anne University Hospital, Brno, Czech Republic

    A Fassmann

  3. Centre for Mathematical Modelling, Masaryk University, Brno, Czech Republic

    V Znojil

Authors
  1. L Izakovičová Hollá
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  2. D Bučková
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  3. A Fassmann
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  4. P Beneš
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  5. V Znojil
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Corresponding author

Correspondence to L Izakovičová Hollá.

Additional information

This study was carried out as part of the project CEZ 307/98:141100002, supported by the Ministry of Education, Youth and Physical Training of the Czech Republic.

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Izakovičová Hollá, L., Bučková, D., Fassmann, A. et al. Plasminogen-activator-inhibitor-1 promoter polymorphism as a risk factor for adult periodontitis in non-smokers. Genes Immun 3, 292–294 (2002). https://doi.org/10.1038/sj.gene.6363874

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