Core–shell noble-metal@zeolitic-imidazolate-framework nanocarriers with high cancer treatment efficiency in vitro

Liangcan He; Kanglei Pang; Wenwen Liu; Yue Tian; Lin Chang; Xu Liu; Meiting Zhao; Yong Liu; Yantao Li; Xingyu Jiang; Rui Song; Yaling Liu

doi:10.1039/C8TB03318H

Core–shell noble-metal@zeolitic-imidazolate-framework nanocarriers with high cancer treatment efficiency in vitro†

Liangcan He,‡^a Kanglei Pang,‡^abc Wenwen Liu,

^a Yue Tian,^a Lin Chang,^a Xu Liu,^a Meiting Zhao,^a Yong Liu,^a Yantao Li,^a Xingyu Jiang,

^a Rui Song

*^b and Yaling Liu

*^a

Author affiliations

* Corresponding authors

^a CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, No. 11, Beiyitiao, Zhongguancun, Beijing 100190, P. R. China
E-mail: liuyl@nanoctr.cn

^b School of Chemical Sciences, University of Chinese Academy of Sciences, No. 19, Yuquan Road, Shijingshan District, Beijing 100049, P. R. China
E-mail: rsong@ucas.ac.cn

^c Sino-Danish College, University of Chinese Academy of Sciences, No. 19, Yuquan Road, Shijingshan District, Beijing 100049, P. R. China

Abstract

Core–shell Au@zeolitic-imidazolate-framework-8 (ZIF-8) nanostructures are reported as a nanocarrier with both a high drug payload and high cancer treatment efficiency in vitro. Impressively, when used as multifunctional drug delivery vehicles, such core–shell Au@ZIF-8 nanostructures not only exhibit light- and pH-controlled drug release properties, but also provide two synergetic therapeutic modes for cancer treatment, resulting in 98% cell-killing activity after 30 min light irradiation followed by 24 h incubation even though HeLa cells are treated only by Au@ZIF-8 nanostructures loaded with 10 μM doxorubicin hydrochloride. All these results demonstrate the promising applications of this type of core–shell nanostructure in biomedical fields.

Journal of Materials Chemistry B

Core–shell noble-metal@zeolitic-imidazolate-framework nanocarriers with high cancer treatment efficiency in vitro†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Core–shell noble-metal@zeolitic-imidazolate-framework nanocarriers with high cancer treatment efficiency in vitro

Social activity

Search articles by author

Spotlight

Advertisements