A facile method for preparing molecularly imprinted polymer spheres using spherical silica templates

Ecevit Yilmaz; Olof Ramström; Per Möller; Domingo Sanchez; Klaus Mosbach

doi:10.1039/B109262F

Ecevit Yilmaz,*^a Olof Ramström,^b Per Möller,^c Domingo Sanchez^c and Klaus Mosbach^a

* Corresponding authors

^a Pure and Applied Biochemistry, Centre for Chemistry and Chemical Engineering, Lund University, POB 124, Lund, Sweden
E-mail: Ecevit.Yilmaz@tbiokem.lth.se
Fax: + 46 46 222 4611
Tel: + 46 46 222 1488

^b Laboratorie de Chimie Supramoléculaire, ISIS-Université Louis Pasteur, 4 rue Blaise Pascal, Strasbourg, France

^c EKA Chemicals AB, Separation Products, Bohus, Sweden

Abstract

A novel and facile preparation method for spherical molecularly imprinted polymer (MIP) beads is presented. Two types of beads were synthesized and investigated: (i) silica–MIP composites were obtained by filling spherical, porous C₄-coated silica beads with print molecule and monomers followed by polymerisation; (ii) spherical molecularly imprinted polymer beads were acquired mirroring the silica particles in size, shape and pore structure by removing the silica matrix from the silica–MIP composites. With regard to their chromatographic properties and yield of the materials both types of particle were more advantageous compared to irregularly shaped traditional MIPs. Also the work-up time to obtain imprinted spherical particles is greatly reduced compared to traditional methods using polymer monoliths, which have to be ground, sieved and sedimented. Generally, the described method may open new possibilities for synthesis of novel types of imprinted polymer formats such as membranes, bulk polymers, films or in-situ columns using appropriate support or sacrificial materials.

Article information

https://doi.org/10.1039/B109262F

Article type

Paper

Submitted

10 Oct 2001

Accepted

25 Jan 2002

First published

15 Mar 2002

Download Citation

J. Mater. Chem., 2002,12, 1577-1581

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