Issue 6, 2009
From the journal:

Green Chemistry

Solvent-free condensations of ketones with malononitrile catalysed by methanesulfonic acid/morpholine system

M. Góra,*a   B. Kozik,a   K. Jamroży,a   M. K. Łuczyński,b   P. Brzuzanc  and  M. Woźnyc  

* Corresponding authors

a Department of Organic Chemistry, Jagiellonian University, ul. Ingardena 3, Kraków, Poland
E-mail: mgora@chemia.uj.edu.pl
Fax: +48-12-6340515
Tel: +48-12-6632907

b Department of Chemistry, University of Warmia and Mazury in Olsztyn, pl. Lódzki 4, Olsztyn, Poland

c Department of Environmental Biotechnology, University of Warmia and Mazury in Olsztyn, ul. Sloneczna 45G, Olsztyn, Poland

Abstract

The preparation of ylidenemalononitriles viaKnoevenagel condensations of ketones with malononitrile under solvent-free conditions is described. Good yields and short reaction time are the features observed with methanesulfonic acid (MSA)/morpholine used as the catalyst. The wide applicability of the protocol is shown by the fact that not only unconjugated, but also aryl-alkyl ketones gave satisfactory yields.

Graphical abstract: Solvent-free condensations of ketones with malononitrile catalysed by methanesulfonic acid/morpholine system

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Article information

DOI
https://doi.org/10.1039/B820901D
Article type
Paper
Submitted
15 Jan 2009
Accepted
10 Mar 2009
First published
26 Mar 2009

Green Chem., 2009,11, 863-867

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Solvent-free condensations of ketones with malononitrile catalysed by methanesulfonic acid/morpholine system

M. Góra, B. Kozik, K. Jamroży, M. K. Łuczyński, P. Brzuzan and M. Woźny, Green Chem., 2009, 11, 863 DOI: 10.1039/B820901D

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