Issue 15, 2005

An iron-catalysed chemo- and regioselective tetrahydrofuran synthesis

Abstract

An intermolecular ring expansion reaction of an aryl epoxide with several dienes, acrylates, enynes or styrenes under iron catalysis, generated tetrahydrofuran derivatives in a highly chemo- and regioselective fashion. The process could be used in an unprecedented way for the one step synthesis of racemic calyxolane A and calyxolane B with acceptable diastereoselectivity.

Graphical abstract: An iron-catalysed chemo- and regioselective tetrahydrofuran synthesis

Supplementary files

Additions and corrections

Article information

Article type
Communication
Submitted
24 Jan 2005
Accepted
11 Feb 2005
First published
18 Feb 2005

Chem. Commun., 2005, 1996-1998

An iron-catalysed chemo- and regioselective tetrahydrofuran synthesis

G. Hilt, P. Bolze and I. Kieltsch, Chem. Commun., 2005, 1996 DOI: 10.1039/B501100K

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