Issue 17, 2010

A unified approach to dielectric single cell analysis: Impedance and dielectrophoretic force spectroscopy

Abstract

In this review we present a unified approach for single cell dielectric spectroscopy. Impedance spectroscopy and dielectrophoretic cell sorting, current microtechnologies applied in electrical analysis of single cells are discussed based on their closely related physical principles. In addition, examples of microfluidic devices will be presented: a microfabricated flow cytometer for single cell discrimination based on impedance analysis and a miniaturized continuous dielectrophoretic cell sorter, both using the concept of liquid electrodes. Using the experimental results obtained from both microdevices, we give a comparative overview over the dielectrophoretic sorting and impedance spectroscopy.

Graphical abstract: A unified approach to dielectric single cell analysis: Impedance and dielectrophoretic force spectroscopy

Supplementary files

Article information

Article type
Critical Review
Submitted
08 Mar 2010
Accepted
16 Jun 2010
First published
28 Jul 2010

Lab Chip, 2010,10, 2216-2225

A unified approach to dielectric single cell analysis: Impedance and dielectrophoretic force spectroscopy

A. Valero, T. Braschler and P. Renaud, Lab Chip, 2010, 10, 2216 DOI: 10.1039/C003982A

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