Issue 7, 2012
From the journal:

Chemical Society Reviews

High-sensitivity nanosensors for biomarker detection†

Magdalena Swierczewska,ab   Gang Liu,ac   Seulki Lee*a  and  Xiaoyuan Chen*a  

* Corresponding authors

a Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), 31 Center Dr 1C22, Bethesda, USA
E-mail: Shawn.Chen@nih.gov, Seulki.Lee@nih.gov
Fax: +1-301-480-1613
Tel: +1-301-451-4246

b Department of Biomedical Engineering, Stony Brook University, Bioengineering Building, Stony Brook, USA

c Sichuan Key Laboratory of Medical Imaging, North Sichuan Medical College, Nanchong 637007, China

Abstract

High sensitivity nanosensors utilize optical, mechanical, electrical, and magnetic relaxation properties to push detection limits of biomarkers below previously possible concentrations. The unique properties of nanomaterials and nanotechnology are exploited to design biomarker diagnostics. High-sensitivity recognition is achieved by signal and target amplification along with thorough pre-processing of samples. In this tutorial review, we introduce the type of detection signals read by nanosensors to detect extremely small concentrations of biomarkers and provide distinctive examples of high-sensitivity sensors. The use of such high-sensitivity nanosensors can offer earlier detection of disease than currently available to patients and create significant improvements in clinical outcomes.

Graphical abstract: High-sensitivity nanosensors for biomarker detection

  • This article is part of the themed collection: Nanomedicine
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Article information

DOI
https://doi.org/10.1039/C1CS15238F
Article type
Tutorial Review
Submitted
04 Sep 2011
First published
20 Dec 2011

Chem. Soc. Rev., 2012,41, 2641-2655

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High-sensitivity nanosensors for biomarker detection

M. Swierczewska, G. Liu, S. Lee and X. Chen, Chem. Soc. Rev., 2012, 41, 2641 DOI: 10.1039/C1CS15238F

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