Issue 12, 2012
From the journal:

Analytical Methods

Interaction of vancomycin with DNA, and determination of DNA via resonance Rayleigh scattering and resonance nonlinear scattering†

Ling Kong,a   Zhongfang Liu,a   Shaopu Liu*a  and  Defeng Wanga  

* Corresponding authors

a Key Laboratory of Luminescence and Real-time Analysis of the Ministry of Education, School of Chemistry and Chemical Engineering, Southwest University, Chongqing, China
E-mail: liusp@swu.edu.cn

Abstract

Assays were developed for DNA based on enhanced resonance Rayleigh scattering and resonance nonlinear scattering (including second order scattering and frequency doubling scattering) that result from the interaction of vancomycin with DNA. Vancomycin possesses the unusual property of promoting the aggregation of DNA, which was concluded from the results obtained with RRS and absorption spectroscopy and from atomic force microscopy. The types of interaction and reasons behind RRS enhancement are discussed. Linear relationships exist over a wide range between the intensity of enhanced scattering and the concentration of DNA. The detection limit (3σ) is in the range of 6.8 to 11.1 ng mL−1.

Graphical abstract: Interaction of vancomycin with DNA, and determination of DNA via resonance Rayleigh scattering and resonance nonlinear scattering

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Supplementary files

Article information

DOI
https://doi.org/10.1039/C2AY26050F
Article type
Paper
Submitted
17 Sep 2012
Accepted
01 Nov 2012
First published
05 Nov 2012

Anal. Methods, 2012,4, 4346-4352

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Interaction of vancomycin with DNA, and determination of DNA via resonance Rayleigh scattering and resonance nonlinear scattering

L. Kong, Z. Liu, S. Liu and D. Wang, Anal. Methods, 2012, 4, 4346 DOI: 10.1039/C2AY26050F

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