Wrinkles occur due to a mechanical instability when sufficient strain is applied to an incompressible thin film attached to a deformable substrate. For wrinkles made with a polymer film supported on a soft elastomer, the amplitude is directly proportional to the wavelength and the square root of the applied strain. This dependence has been confirmed with ideal substrates where the global strain is homogeneously distributed, but the influence of strain inhomogeneity has not been considered previously. We use the contact line wrinkling technique to prepare polystyrene thin films with periodic regions of different wrinkle amplitudes, hence strains, on soft substrates. We find that an inhomogeneously strained surface approaches amplitude homogeneity globally upon the application of sufficiently large strains. We derive relationships to describe this process, providing fundamental knowledge of the wrinkling mechanism.