Issue 2, 2015
From the journal:

Analytical Methods

Designing a nanostructure-based modified electrode as a biosensor for simultaneous determination of tryptophan and uric acid

Sayed Mehdi Ghoreishi,*a   Mohsen Behpour,a   Samira Mousavi,a   Asma Khoobia  and  Farzaneh Sadat Ghoreishia  

* Corresponding authors

a Department of Analytical Chemistry, Faculty of Chemistry, University of Kashan, P.O. Box 87317-51167, Kashan, I. R. Iran
E-mail: s.m.ghoreishi@kashanu.ac.ir
Fax: +983155552930
Tel: +983155912395

Abstract

A carbon paste electrode modified with multi-walled carbon nanotubes (CPE-MWCNTs) was prepared for the simultaneous determination of tryptophan (Trp) and uric acid (UA). The surface morphology of the modified electrode was characterized by scanning electron microscopy (SEM) and electrochemical impedance spectroscopy (EIS). Cyclic voltammetry (CV), chronocoulometric and differential pulse voltammetry (DPV) techniques were used to investigate the modified electrode for the electrocatalytic oxidation of Trp and UA in aqueous solutions. Using the modified electrode the separation of the oxidation peak potentials for Trp and UA was obtained to be 386.0 mV. Also the dynamic ranges for Trp and UA were achieved to be 0.6–100.0 and 0.4–100.0 μM, respectively. The detection limits (S/N = 3) were 0.06 and 0.03 μM for Trp and UA, respectively.

Graphical abstract: Designing a nanostructure-based modified electrode as a biosensor for simultaneous determination of tryptophan and uric acid

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Article information

DOI
https://doi.org/10.1039/C4AY02252A
Article type
Paper
Submitted
24 Sep 2014
Accepted
09 Nov 2014
First published
10 Nov 2014

Anal. Methods, 2015,7, 466-471

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Designing a nanostructure-based modified electrode as a biosensor for simultaneous determination of tryptophan and uric acid

S. M. Ghoreishi, M. Behpour, S. Mousavi, A. Khoobi and F. S. Ghoreishi, Anal. Methods, 2015, 7, 466 DOI: 10.1039/C4AY02252A

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