Issue 33, 2014

Access to novel functionalized trifluoromethyl β-lactams by ring expansion of aziridines

Abstract

From carboxylic acid trifluoromethyl aziridines, halogeno β-lactams were obtained stereoselectively by ring expansion. Different conditions such as radical, organometallic reactions allowed easy and selective access to CF3-β-lactams substituted at the C-3 position.

Graphical abstract: Access to novel functionalized trifluoromethyl β-lactams by ring expansion of aziridines

Supplementary files

Article information

Article type
Communication
Submitted
17 Jun 2014
Accepted
08 Jul 2014
First published
08 Jul 2014

Org. Biomol. Chem., 2014,12, 6345-6348

Access to novel functionalized trifluoromethyl β-lactams by ring expansion of aziridines

S. Decamps, L. Sevaille, S. Ongeri and B. Crousse, Org. Biomol. Chem., 2014, 12, 6345 DOI: 10.1039/C4OB01262C

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