A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function

J. Broichhagen; J. A. Frank; N. R. Johnston; R. K. Mitchell; K. Šmid; P. Marchetti; M. Bugliani; G. A. Rutter; D. Trauner; D. J. Hodson

doi:10.1039/C5CC01224D

A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function†

J. Broichhagen,^a J. A. Frank,^a N. R. Johnston,^b R. K. Mitchell,^b K. Šmid,^a P. Marchetti,^c M. Bugliani,^c G. A. Rutter,^b D. Trauner*^a and D. J. Hodson*^b

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* Corresponding authors

^a Department of Chemistry and Center for Integrated Protein Science, LMU Munich, Munich, Germany
E-mail: dirk.trauner@lmu.de

^b Section of Cell Biology and Functional Genomics, Department of Medicine, Imperial College London, London W12 0NN, UK
E-mail: d.hodson@imperial.ac.uk

^c Department of Clinical and Experimental Medicine, Islet Cell Laboratory, University of Pisa, Pisa, Italy

Abstract

Azobenzene photoresponsive elements can be installed on sulfonylureas, yielding optical control over pancreatic beta cell function and insulin release. An obstacle to such photopharmacological approaches remains the use of ultraviolet-blue illumination. Herein, we synthesize and test a novel yellow light-activated sulfonylurea based on a heterocyclic azobenzene bearing a push–pull system.

Chemical Communications

A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function†

Abstract

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