Issue 63, 2015
From the journal:

Chemical Communications

Synthesis of self-reporting polymeric nanoparticles for in situ monitoring of endocytic microenvironmental pH†

Zeng-Ying Qiao,a   Chun-Yuan Hou,a   Wen-Jing Zhao,a   Di Zhang,a   Pei-Pei Yang,a   Lei Wang*a  and  Hao Wang*a  

* Corresponding authors

a CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Beijing 100190, China
E-mail: wanghao@nanoctr.cn, wanglei@nanoctr.cn

Abstract

The bis(pyrene) conjugated pH-sensitive polymers (P-BP) were synthesized and self-assembled into nanoparticles through hydrophobic interactions. The Nile red (NR) loaded P-BP nanoparticles showed red emission due to the FRET effect. The nanoparticles entered cells via endocytosis, and the microenvironmental pH in the endocytosis process was monitored in situ by the simultaneous dual-wavelength fluorescence changes.

Graphical abstract: Synthesis of self-reporting polymeric nanoparticles for in situ monitoring of endocytic microenvironmental pH

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Article information

DOI
https://doi.org/10.1039/C5CC03752B
Article type
Communication
Submitted
06 May 2015
Accepted
30 Jun 2015
First published
30 Jun 2015

Chem. Commun., 2015,51, 12609-12612

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Synthesis of self-reporting polymeric nanoparticles for in situ monitoring of endocytic microenvironmental pH

Z. Qiao, C. Hou, W. Zhao, D. Zhang, P. Yang, L. Wang and H. Wang, Chem. Commun., 2015, 51, 12609 DOI: 10.1039/C5CC03752B

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