Issue 26, 2015
From the journal:

CrystEngComm

Designed preparation of polyacrylic acid/calcium carbonate nanoparticles with high doxorubicin payload for liver cancer chemotherapy†

Hanzhu Shi,a   Lu Li,a   Lingyu Zhang,a   Tingting Wang,*b   Chungang Wang,*a   Dongxia Zhua  and  Zhongmin Sua  

* Corresponding authors

a Faculty of Chemistry, Northeast Normal University, Changchun, PR China
E-mail: wangcg925@nenu.edu.cn

b School of Chemistry & Environmental Engineering, Changchun University of Science and Technology, Changchun, PR China
E-mail: wangtt@cust.edu.cn

Abstract

Polyacrylic acid (PAA)/calcium carbonate (CaCO3) nanoparticles (NPs) were synthesized via a simple and novel strategy. The as-prepared PAA/CaCO3 NPs not only exhibit ultrahigh doxorubicin (DOX) payload (1.18 g of DOX per g of NPs) but also possess pH-sensitive drug release properties. In vivo experiments show that the DOX-loaded PAA/CaCO3 NPs display a significant antitumor effect (76% average inhibition rate relative to the control group) without distinct side effects. Therefore, PAA/CaCO3 NPs are promising candidates for cancer therapy as efficient drug delivery vehicles.

Graphical abstract: Designed preparation of polyacrylic acid/calcium carbonate nanoparticles with high doxorubicin payload for liver cancer chemotherapy

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C5CE00708A
Article type
Communication
Submitted
12 Apr 2015
Accepted
19 May 2015
First published
20 May 2015

CrystEngComm, 2015,17, 4768-4773

Permissions

Request permissions

Designed preparation of polyacrylic acid/calcium carbonate nanoparticles with high doxorubicin payload for liver cancer chemotherapy

H. Shi, L. Li, L. Zhang, T. Wang, C. Wang, D. Zhu and Z. Su, CrystEngComm, 2015, 17, 4768 DOI: 10.1039/C5CE00708A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements