Issue 62, 2015
From the journal:

RSC Advances

Non-covalent functionalization of carbon nano-onions with pyrene–BODIPY dyads for biological imaging†

Juergen Bartelmess,‡a   Marco Frasconi,‡a   Preethi B. Balakrishnan,b   Angelo Signorelli,a   Luis Echegoyen,c   Teresa Pellegrinob  and  Silvia Giordani*a  

* Corresponding authors

a Istituto Italiano di Tecnologia (IIT), Nano Carbon Materials Lab, Via Morego 30, 16163 Genova, Italy
E-mail: silvia.giordani@iit.it

b Istituto Italiano di Tecnologia (IIT), Drug Discovery and Development Department, Via Morego 30, 16163 Genova, Italy

c University of Texas at El Paso, Department of Chemistry, 500 W. University Ave., El Paso, TX 79968, USA

Abstract

We report a novel approach based on non-covalent interactions for the functionalization of carbon nano-onions (CNOs) with fluorophores. The assembly of pyrene–BODIPY conjugates on the CNO surface by means of π–π-stacking results in fluorescent carbon nanoparticles that are successfully uptaken by HeLa cancer cells with no cytotoxicity observed. The ability to functionalize carbon-based nanomaterials by using mild conditions will pave the way for future clinical application of these versatile nanomaterials.

Graphical abstract: Non-covalent functionalization of carbon nano-onions with pyrene–BODIPY dyads for biological imaging

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Article information

DOI
https://doi.org/10.1039/C5RA07683H
Article type
Paper
Submitted
27 Apr 2015
Accepted
29 May 2015
First published
29 May 2015

RSC Adv., 2015,5, 50253-50258

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Non-covalent functionalization of carbon nano-onions with pyrene–BODIPY dyads for biological imaging

J. Bartelmess, M. Frasconi, P. B. Balakrishnan, A. Signorelli, L. Echegoyen, T. Pellegrino and S. Giordani, RSC Adv., 2015, 5, 50253 DOI: 10.1039/C5RA07683H

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