Issue 115, 2015
From the journal:

RSC Advances

Phialomustin A–D, new antimicrobial and cytotoxic metabolites from an endophytic fungus, Phialophora mustea†

Yedukondalu Nalli,ab   Dania N. Mirza,bc   Zahoor A. Wani,bc   Bhumika Wadhwa,bd   Fayaz A. Mallik,bd   Chand Raina,e   Asha chaubey,e   Syed Riyaz-Ul-Hassan*bc  and  Asif Ali*ab  

* Corresponding authors

a Natural Product Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India
E-mail: asifali@iiim.ac.in
Fax: +91-191-2569333
Tel: +91-191-2569111

b Academy of Scientific and Innovative Research (AcSIR), Anusandhan Bhawan, 2 Rafi Marg, New Delhi-110001, India

c Microbial Biotechnology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India
E-mail: srhassan@iiim.ac.in

d Cancer Pharmacology Division, Indian Institute of Integrative Medicine (CSIR), Canal Road, Jammu-180001, India

e Fermentation Division, Indian Institute of Integrative Medicine (CSIR), Canal Road, Jammu-180001, India

Abstract

Phialomustin A–D (1–4), four new bioactive metabolites, with an unprecedented azaphilone derived skeleton, were isolated and characterized from an endophytic fungus isolated from Crocus sativus. The ITS-5.8S-ITS2 ribosomal gene sequence of the endophyte displayed a sequence similarity of more than 99% with Phialophora mustea. The structural determinations of compounds (1–4) were authenticated by spectroscopic and chemical analysis. The absolute configuration of the stereogenic centers of 1, 3 and 4 were determined by electronic circular dichroism spectroscopy. Compounds 3 and 4 showed promising antifungal activities against Candida albicans, with IC50 values of 14.3 and 73.6 μM, whereas compound 2 exhibited remarkable cytotoxic activity against the human breast cancer cell line, T47D, with an IC50 of 1 μM.

Graphical abstract: Phialomustin A–D, new antimicrobial and cytotoxic metabolites from an endophytic fungus, Phialophora mustea

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Article information

DOI
https://doi.org/10.1039/C5RA18121F
Article type
Paper
Submitted
05 Sep 2015
Accepted
14 Oct 2015
First published
05 Nov 2015

RSC Adv., 2015,5, 95307-95312

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Phialomustin A–D, new antimicrobial and cytotoxic metabolites from an endophytic fungus, Phialophora mustea

Y. Nalli, D. N. Mirza, Z. A. Wani, B. Wadhwa, F. A. Mallik, C. Raina, A. chaubey, S. Riyaz-Ul-Hassan and A. Ali, RSC Adv., 2015, 5, 95307 DOI: 10.1039/C5RA18121F

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