Issue 7, 2016
From the journal:

RSC Advances

Curcumin loaded on pullulan acetate nanoparticles protects the liver from damage induced by DEN†

Moorthy Ganeshkumar,a   Thangavel Ponrasu,a   Muthaiya Kannappan Subamekala,b   Murthy Jananib  and  Lonchin Suguna*a  

* Corresponding authors

a Department of Biochemistry, CSIR-Central Leather Research Institute, Council of Scientific and Industrial Research, Adyar, Chennai 600020, India
E-mail: slonchin@yahoo.co.uk, slonchin@hotmail.com
Fax: +91-44-24911589
Tel: +91-44-24911386

b Department of Biopharmaceutics, Anna University, Chennai, India

Abstract

In recent years, nanoparticle based drug delivery has been used to treat liver diseases. Even though curcumin is a potent antioxidant, reactive oxygen species (ROS) scavenger and anti-inflammatory agent, its use at a clinical level is very limited due to its poor bioavailability rendered by its physiochemical properties. In this study, biodegradable liver specific pullulan acetate nanoparticles (PA) loaded with curcumin were developed for the first time. These curcumin loaded PA nanoparticles were found to improve the encapsulation efficiency and stability of curcumin with sustained release, under physiological conditions. Thus, curcumin loaded pullulan acetate nanoparticles (PAC) could solve the physicochemical defects of curcumin like solubility, pH stability, photo-stability, and be used as an effective hepato-protective agent against diethyl nitrosamine (DEN) induced liver damage.

Graphical abstract: Curcumin loaded on pullulan acetate nanoparticles protects the liver from damage induced by DEN

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Article information

DOI
https://doi.org/10.1039/C5RA18989F
Article type
Paper
Submitted
15 Sep 2015
Accepted
03 Jan 2016
First published
07 Jan 2016

RSC Adv., 2016,6, 5599-5610

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Curcumin loaded on pullulan acetate nanoparticles protects the liver from damage induced by DEN

M. Ganeshkumar, T. Ponrasu, M. K. Subamekala, M. Janani and L. Suguna, RSC Adv., 2016, 6, 5599 DOI: 10.1039/C5RA18989F

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