Issue 32, 2016
From the journal:

RSC Advances

Nanoscale graphene coating on commercially pure titanium for accelerated bone regeneration†

Ho Sang Jung,a   Yeong-jin Choi,b   Jiwon Jeong,a   Yongmoon Lee,c   Byungwoo Hwang,a   Jinah Jang,b   Jin-Hyung Shim,d   Yun Seop Kim,a   Hyun Sik Choi,a   Sang Ho Oh,a   Chong Soo Lee,c   Dong-Woo Choe  and  Sei Kwang Hahn*a  

* Corresponding authors

a Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Kyungbuk 790-784, South Korea
E-mail: skhanb@postech.ac.kr

b Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), 77 Cheong-Am Ro, Nam-gu, Pohang, Kyungbuk 790-784, South Korea

c Graduate Institute of Ferrous Technology (GIFT), Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Kyungbuk 790-784, South Korea

d Department of Mechanical Engineering, Korea Polytechnic University, 2121 Jeongwang-dong, Siheung-si, Gyeonggi-do 429-793, South Korea

e Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheong-Am Ro, Nam-gu, Pohang, Kyungbuk 790-784, South Korea

Abstract

Titanium (Ti) is one of the representative biocompatible metallic materials which has been widely exploited for various implants and bone replacements. Here, commercially pure Ti (CP Ti) was surface-modified with reduced graphene oxide (RGO) for accelerated bone regeneration and osseointegration. Nanoscale RGO coating on CP Ti was clearly confirmed by SEM, AFM, EDS, XPS, HR-TEM and EELS. In addition, pre-osteoblast cells cultured on RGO-CP Ti showed higher cell viability and cell attachment than those on CP Ti. After confirmation of the drug loading capability of RGO-CP Ti, osteogenic dexamethasone loaded RGO-CP Ti (Dex/RGO-CP Ti) was implanted on calvarial bone defects in rats. Synchrotron X-ray imaging successfully visualized more effective bone regeneration on Dex/RGO-CP Ti than CP Ti and RGO-CP Ti after 8 weeks.

Graphical abstract: Nanoscale graphene coating on commercially pure titanium for accelerated bone regeneration

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Article information

DOI
https://doi.org/10.1039/C6RA03905G
Article type
Communication
Submitted
12 Feb 2016
Accepted
02 Mar 2016
First published
04 Mar 2016
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2016,6, 26719-26724

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Nanoscale graphene coating on commercially pure titanium for accelerated bone regeneration

H. S. Jung, Y. Choi, J. Jeong, Y. Lee, B. Hwang, J. Jang, J. Shim, Y. S. Kim, H. S. Choi, S. H. Oh, C. S. Lee, D. Cho and S. K. Hahn, RSC Adv., 2016, 6, 26719 DOI: 10.1039/C6RA03905G

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