Nanoparticles in sonodynamic therapy: state of the art review

Hongyan Xu; Xia Zhang; Rubing Han; Peimin Yang; Haifeng Ma; Yan Song; Zhichao Lu; Weidong Yin; XiangXia Wu; Hui Wang

doi:10.1039/C6RA06862F

Nanoparticles in sonodynamic therapy: state of the art review

Hongyan Xu,^a Xia Zhang,^a Rubing Han,^a Peimin Yang,^a Haifeng Ma,*^a Yan Song,^a Zhichao Lu,^a Weidong Yin,^a XiangXia Wu^a and Hui Wang^a

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^a Department of Pharmacy, People′s Hospital of Linzi District, Linzi, Shandong Province, China
E-mail: hfma0533@126.com
Tel: +86-533-7162081

Abstract

Sonodynamic therapy (SDT) is a novel therapeutic platform that involves a combination of low-intensity ultrasound and special bioagents called sonosensitizers. The application of nanoparticle technology substantially alters the concepts of traditional SDT. It has great potential to address many shortcomings which frequently trouble the clinical use of SDT, and paves the way for more effective yet safer therapeutic options. In this review, we systematically describe and compare the different individual types of nanoparticle that are being developed for SDT. Recent advances in the use of nanoparticles as sonosensitizers themselves or as carriers for sonosensitizer delivery are highlighted. Furthermore, potential limitations and future perspectives are also presented.

RSC Advances

Nanoparticles in sonodynamic therapy: state of the art review

Abstract

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