Talaramide A, an unusual alkaloid from the mangrove endophytic fungus Talaromyces sp. (HZ-YX1) as an inhibitor of mycobacterial PknG

Senhua Chen; Liqing He; Dongni Chen; Runlin Cai; Yuhua Long; Yongjun Lu; Zhigang She

doi:10.1039/C7NJ00059F

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Talaramide A, an unusual alkaloid from the mangrove endophytic fungus Talaromyces sp. (HZ-YX1) as an inhibitor of mycobacterial PknG†

Senhua Chen,

^a Liqing He,^ab Dongni Chen,^c Runlin Cai,^a Yuhua Long,^a Yongjun Lu*^c and Zhigang She*^a

Author affiliations

* Corresponding authors

^a School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China
E-mail: cesshzhg@mail.sysu.edu.cn
Fax: +86-20-8411-3356
Tel: +86-20-8411-3356

^b Department of Light Industry and Chemical Engineering, Guangdong Polytechnic College, Foshan 528000, Guangdong Province, China

^c School of Life Sciences and Biomedical Center, Sun Yat-Sen University, Guangzhou 510275, China
E-mail: luyj@mail.sysu.edu.cn

Abstract

An unusual alkaloid, talaramide A (1), was obtained from the mangrove endophytic fungus Talaromyces sp. (HZ-YX1). The structure of 1 was established by analysis of NMR spectroscopic data, X-ray diffraction data, and electronic circular dichroism (ECD) spectra. Talaramide A (1) is the second example of an alkaloid that possesses a unique oxidized tricyclic system. A possible biosynthetic pathway for 1 was proposed. Compound 1 showed promising inhibition of mycobacterial PknG activity with an IC₅₀ value of 55 μM.

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Article information

DOI: https://doi.org/10.1039/C7NJ00059F
Article type: Letter
Submitted: 05 Jan 2017
Accepted: 11 Apr 2017
First published: 12 Apr 2017

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New J. Chem., 2017,41, 4273-4276

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Talaramide A, an unusual alkaloid from the mangrove endophytic fungus Talaromyces sp. (HZ-YX1) as an inhibitor of mycobacterial PknG

S. Chen, L. He, D. Chen, R. Cai, Y. Long, Y. Lu and Z. She, New J. Chem., 2017, 41, 4273 DOI: 10.1039/C7NJ00059F

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New Journal of Chemistry

Talaramide A, an unusual alkaloid from the mangrove endophytic fungus Talaromyces sp. (HZ-YX1) as an inhibitor of mycobacterial PknG†

Abstract

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Talaramide A, an unusual alkaloid from the mangrove endophytic fungus Talaromyces sp. (HZ-YX1) as an inhibitor of mycobacterial PknG

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