Issue 54, 2017, Issue in Progress
From the journal:

RSC Advances

Non-leaching antibacterial cotton fabrics based on lipidated peptides†

A. Opitakorn,a   M. Rauytanapanit,a   R. Waditee-Sirisatthab  and  T. Praneenararat ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Faculty of Science, Chulalongkorn University, Phayathai Rd., Pathumwan, Bangkok, Thailand
E-mail: Thanit.P@chula.ac.th

b Department of Microbiology, Faculty of Science, Chulalongkorn University, Phayathai Rd., Pathumwan, Bangkok, Thailand

Abstract

A set of lipidated peptides was in situ synthesised on cotton fabrics using Fmoc-based peptide synthesis. The resulting modified surfaces exhibit highly potent antibacterial activities in two Gram-negative bacteria including Escherichia coli (ATCC 8739) and Pseudomonas aeruginosa (ATCC 9027), along with moderate antibacterial activities in a Gram-positive bacterium Staphylococcus aureus (ATCC 6538P). As anticipated from covalently bound antimicrobial moieties, a representative membrane disintegration assay suggested that the modified surfaces inhibited bacteria by disrupting the integrity of bacterial cell membranes. Without non-natural D-peptides used in previous studies, this new class of non-leaching antibacterial surfaces offer potent activities while having more practical and economical productions. Furthermore, biocompatibility studies suggest that a selected set of surfaces show no toxicity, thus rendering them suitable for biomedical applications.

Graphical abstract: Non-leaching antibacterial cotton fabrics based on lipidated peptides

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Article information

DOI
https://doi.org/10.1039/C7RA03565A
Article type
Paper
Submitted
27 Mar 2017
Accepted
30 Jun 2017
First published
07 Jul 2017
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2017,7, 34267-34275

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Non-leaching antibacterial cotton fabrics based on lipidated peptides

A. Opitakorn, M. Rauytanapanit, R. Waditee-Sirisattha and T. Praneenararat, RSC Adv., 2017, 7, 34267 DOI: 10.1039/C7RA03565A

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