A systematic application of intercalation techniques to layered superconducting oxides enables us to open a new chapter in the development of nano-hybrids with various functions. Recently we were successful in preparing a new series of inorganic-inorganic nano-hybrids, M-X-Bi ₂ Sr ₂ Ca _m–1 Cu _m O _y (M=Hg, Ag, Au; X=Br, I; m=1-3) and organic-inorganic ones, R ₂ HgI ₄ -Bi ₂ Sr ₂ Ca _m–1 Cu _m O _y (R=organic cation). Our synthetic strategies are based on (1) HSAB (hard-soft acid-base) interactions and (2) interlayer complexation concepts. Since the iodine species in IBi ₂ Sr ₂ Ca _m–1 Cu _m O _y are stabilized as I3– (soft base) with a charge transfer between host and guest, soft Lewis acids like Ag ⁺ , Au ⁺ , and Hg ²⁺ can be further intercalated into the iodine layers inbetween the (Bi-O) double layers. On the other hand, new organic-inorganic nano-hybrids (R ₂ HgI ₄ -Bi ₂ Sr ₂ Ca _m–1 Cu _m O _y ) have also been achieved through the intercalative complex-salt formation reaction between preintercalated HgI ₂ molecules and R ⁺ I ^– salts in the interlayer space of Bi ₂ Sr ₂ Ca _m–1 Cu _m O _y . Compared to the pure compounds the superconducting transition temperatures of the organic-salt intercalates are little changed even with a large basal increment upon intercalation, indicating a two-dimensional nature of the high-T  _c superconductivity. From the viewpoint of application, the intercalation of large organic molecules provides a new synthetic route to high-T  _c superconducting thin-film and nano-particles by separating superconducting blocks into isolated single sheets.