Issue 10, 2002
From the journal:

Journal of Materials Chemistry

Cu2+- and Ag+-complexes with a hyaluronane-based hydrogel

Rolando Barbucci,*a   Gemma Leone,a   Agnese Magnani,a   Lucio Montanaro,b   Carla R. Arciola,b   Gianfranco Pelusoc  and  Orsolina Petilloc  

* Corresponding authors

a CRISMA and Department of Chemical and Biosystems Sciences and Technologies, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy

b Laboratorio di Biocompatibilità dei Materiali da Impianto, Istituti Ortopedici Rizzoli, Via di Barbiano 1/10, 40136 Bologna, Italy

c Istituto di Biochimica, delle Proteine ed Enzimologia, Consiglio Nazionale delle Ricerche, Via Toiano 6 Arco Felice, Napoli, Italy

Abstract

Copper(II) and silver(I) hyaluronane-based hydrogel complexes were synthesised. The amount of metal ion uptaken by hydrogel was determined by atomic absorption and the hydrogel–metal ion complexes were characterised by water-uptake measurements, SEM-EDAX and FT-IR analysis. The coordination sites were identified for both metal ions and the stability at various pH levels was determined. The cytotoxicity of hydrogel metal ions was evaluated by using fibroblast (3T3) cells. The copper(II) complex was “in vivo” tested and showed proangiogenic activity, stimulating the growth of new vessels without inducing an inflammatory reaction.

The antibacterial activity of a silver complex was determined, showing that the presence of silver ions drastically reduced the adhesion and proliferation of Staphylococcus epidermidis.

Graphical abstract: Cu2+- and Ag+-complexes with a hyaluronane-based hydrogel

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Article information

DOI
https://doi.org/10.1039/B205320A
Article type
Paper
Submitted
31 May 2002
Accepted
29 Jul 2002
First published
02 Sep 2002

J. Mater. Chem., 2002,12, 3084-3092

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Cu2+- and Ag+-complexes with a hyaluronane-based hydrogel

R. Barbucci, G. Leone, A. Magnani, L. Montanaro, C. R. Arciola, G. Peluso and O. Petillo, J. Mater. Chem., 2002, 12, 3084 DOI: 10.1039/B205320A

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