How hazardous are ionic liquids? Structure–activity relationships and biological testing as important elements for sustainability evaluation

Bernd Jastorff; Reinhold Störmann; Johannes Ranke; Kerstin Mölter; Frauke Stock; Boris Oberheitmann; Wolfgang Hoffmann; Jens Hoffmann; Matthias Nüchter; Bernd Ondruschka; Juliane Filser

doi:10.1039/B211971D

How hazardous are ionic liquids? Structure–activity relationships and biological testing as important elements for sustainability evaluation†

Bernd Jastorff,^a Reinhold Störmann,^a Johannes Ranke,^a Kerstin Mölter,^b Frauke Stock,^a Boris Oberheitmann,^c Wolfgang Hoffmann,^cd Jens Hoffmann,^e Matthias Nüchter,^e Bernd Ondruschka^e and Juliane Filser^b

Author affiliations

^a UFT Centre for Environmental Research and Environmental Technology, Department of Bioorganic Chemistry, Leobener Straße, 28359 Bremen, Germany
E-mail: jastorff@uni-bremen.de

^b UFT Centre for Environmental Research and Environmental Technology, Department of General and Theoretical Ecology, Leobener Straße, 28359 Bremen, Germany

^c UFT Centre for Environmental Research and Environmental Technology, Department of Epidemiology, Leobener Straße, 28359 Bremen, Germany

^d Ernst-Moritz-Arndt-Universität Greifswald, Institute for Community Medicine, Ellernholzstr. 1-2, 17487 Greifswald, Germany

^e Institute of Technical Chemistry and Environmental Chemistry, Friedrich-Schiller-University of Jena, Lessingstraße 12, 07743 Jena, Germany

Abstract

For ionic liquids only few toxicological and/or ecotoxicological data are available until now. A strategy is presented which aims at an environmental risk assessment of chemicals, using a combination of structure–activity relationships (SAR), toxicological and ecotoxicological tests and modelling. The parts “test-kit-concept” and “multidimensional risk analysis” are described in detail by means of selected imidazolium ionic liquids. The iterative process of this strategy offers a tool for sustainable product design.

Green Chemistry

How hazardous are ionic liquids? Structure–activity relationships and biological testing as important elements for sustainability evaluation†

Abstract

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