Issue 12, 2003
From the journal:

Organic & Biomolecular Chemistry

Synthesis of carbohydrate derivatives using solid-phase work-up and scavenging techniques

Rachel N. MacCoss,a   Paul E. Brennana  and  Steven V. Ley*a  

* Corresponding authors

a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: svl1000@cam.ac.uk

Abstract

Methods to allow the clean preparation of oligosaccharides were investigated using techniques that do not require conventional column chromatography or an aqueous work-up. The route was designed to provide rapid access to oligosaccharides and is suitable for automation and parallel library formation. The research has focused on the glycosidations of a range of glycosyl acceptors with various selenophenyl glycosyl donors using iodine as an activator in the presence of DTBMP, a hindered organic base. Hydroxyl-containing contaminants were removed by scavenging with polymer-supported tosyl chloride.

Graphical abstract: Synthesis of carbohydrate derivatives using solid-phase work-up and scavenging techniques

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Article information

DOI
https://doi.org/10.1039/B303951J
Article type
Communication
Submitted
08 Apr 2003
Accepted
12 May 2003
First published
19 May 2003

Org. Biomol. Chem., 2003,1, 2029-2031

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Synthesis of carbohydrate derivatives using solid-phase work-up and scavenging techniques

R. N. MacCoss, P. E. Brennan and S. V. Ley, Org. Biomol. Chem., 2003, 1, 2029 DOI: 10.1039/B303951J

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