Issue 3, 2006
From the journal:

Lab on a Chip

Miniaturized continuous flow reaction vessels: influence on chemical reactions

Monica Brivio,a   Willem Verbooma  and  David N. Reinhoudta  

a Laboratory of Supramolecular Chemistry and Technology, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands
E-mail: w.verboom@utwente.nl
Fax: +31 (0)53 4894645
Tel: +31 (0)53 4892977

Abstract

This review offers an overview of the relatively young research area of continuous flow lab-on-a-chip for synthetic applications. A short introduction on the basic aspects of lab-on-a-chip is given in the first part. Subsequently, the effects of downscaling reaction vessels as well as the advantages of the continuous flow microfluidic approach over conventional chemical laboratory batch methodologies are illustrated by a number of examples of organic reactions carried out in microfluidic devices. The last part deals with a key issue of the lab-on-a-chip approach, viz. the integration of the microreactor with the analytical instrumentation to achieve high-throughput reaction monitoring.

Graphical abstract: Miniaturized continuous flow reaction vessels: influence on chemical reactions

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Article information

DOI
https://doi.org/10.1039/B510856J
Article type
Critical Review
Submitted
29 Jul 2005
Accepted
23 Dec 2005
First published
20 Jan 2006

Lab Chip, 2006,6, 329-344

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Miniaturized continuous flow reaction vessels: influence on chemical reactions

M. Brivio, W. Verboom and D. N. Reinhoudt, Lab Chip, 2006, 6, 329 DOI: 10.1039/B510856J

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