Issue 3, 2006
From the journal:

Lab on a Chip

Microfluidic sorting system based on optical waveguide integration and diode laser bar trapping

Robert W. Applegate Jr.,*a   Jeff Squier,a   Tor Vestad,b   John Oakey,bc   David W. M. Marr,c   Philippe Bado,d   Mark A. Dugand  and  Ali A. Saidd  

* Corresponding authors

a Department of Physics, Colorado School of Mines, 1523 Illinois Street, Golden, CO 80401, USA
E-mail: rapplega@mines.edu

b MetaFluidics Inc., Golden, CO 80401, USA

c Department of Chemical Engineering, Colorado School of Mines, Golden, CO 80401, USA

d Translume Inc., Ann Arbor, MI 48108, USA

Abstract

Effective methods for manipulating, isolating and sorting cells and particles are essential for the development of microfluidic-based life science research and diagnostic platforms. We demonstrate an integrated optical platform for cell and particle sorting in microfluidic structures. Fluorescent-dyed particles are excited using an integrated optical waveguide network within micro-channels. A diode-bar optical trapping scheme guides the particles across the waveguide/micro-channel structures and selectively sorts particles based upon their fluorescent signature. This integrated detection and separation approach streamlines microfluidic cell sorting and minimizes the optical and feedback complexity commonly associated with extant platforms.

Graphical abstract: Microfluidic sorting system based on optical waveguide integration and diode laser bar trapping

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Article information

DOI
https://doi.org/10.1039/B512576F
Article type
Paper
Submitted
08 Sep 2005
Accepted
05 Jan 2006
First published
20 Jan 2006

Lab Chip, 2006,6, 422-426

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Microfluidic sorting system based on optical waveguide integration and diode laser bar trapping

R. W. Applegate Jr., J. Squier, T. Vestad, J. Oakey, D. W. M. Marr, P. Bado, M. A. Dugan and A. A. Said, Lab Chip, 2006, 6, 422 DOI: 10.1039/B512576F

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